Aaron Mackey
Senior Fellow, Scientific AI at McKinsey & Company
Greater Philadelphia United States
Summary
👤
Senior🎓
Top SchoolAaron Mackey is a Senior Fellow in Scientific AI with 27 years of experience building integrated statistical and machine learning systems that extract causal, actionable insights from multi-omic, clinical trial, and real-world health data. He has led and scaled cross-functional teams in industry and academia—transforming predictive ML into prescriptive, CausalAI-enabled recommendation engines for clinical trial optimization and drug discovery. His work spans hands-on algorithm development, production software, and open-source contributions (including core BioPerl database modules), reflecting a rare blend of computational genomics and product-focused engineering. Aaron regularly teaches and mentors the next generation of computational scientists through Cold Spring Harbor and university roles, while advising startups and serving on industry councils. He emphasizes models that jointly leverage multiple datasets to boost signal-to-noise and reveal relationships invisible in isolation, then translates those findings into experiments and decisions. Based in Greater Philadelphia, he stays current through grant review, conferences, and active collaboration across biology, statistics, and AI.
27 years of coding experience
11 years of employment as a software developer
B.A. Biochemistry and Molecular Biology, B.A. Biochemistry and Molecular Biology at Reed CollegeM.S. Immunology, M.S. Immunology at Washington University in St. LouisHigh School Diploma, High School Diploma at Breck SchoolPhD Microbiology Computational Biology, PhD Microbiology Computational Biology at University of Virginia
English, French, Dutch, Japanese, Finnish, Spanish
Github Skills (8)
bioinformatics10
bioperl10
perl10
database9
databases9
api8
apidoc8
sequence-analysis7
Programming languages (3)
Github contributions (5)
bioperl/bioperl-live
Feb 1999 - May 2011
Core BioPerl 1.x code
Role in this project:
Back-end Developer
Back-end DeveloperContributions:140 commits in 12 years 5 months
Contributions summary:Aaron primarily contributed to the BioPerl project, focusing on the development of database modules. Their work involved creating modules to retrieve sequences from GenBank, utilizing external tools for data retrieval and parsing. The user refactored code, improved functionality, and refactored code to leverage more modern libraries for data retrieval.
bioperlbioinformaticsperltoolkit
amackey/cascada-poc
Jun 2026 - Jun 2026
Contributions:3 pushes, 1 branch in 1 day
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