Alexander Payne
New York City Metropolitan Area United States
Summary
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Rockstar🎓
Top SchoolAlexander Payne is a computational biophysicist and PhD candidate with six years of hands-on experience using molecular dynamics, cryo-EM, and machine learning tools to probe protein dynamics for drug discovery and protein design. He has contributed to open science drug-discovery pipelines (including work on SARS-CoV-2 main protease datasets), run Folding@home simulations, and built reproducible analysis repositories while collaborating across international teams. Experienced as an instructor and mentor, he has taught graduate biophysics courses and developed curriculum-style lectures on applications of statistical mechanics to biological problems. Equally comfortable in Python, Rosetta, CHARMM-GUI/OpenMM, and cryo-EM toolchains, he combines rigorous computational technique with a passion for education and science outreach. Alexander is particularly interested in leveraging deep neural networks to map protein dynamics to allosteric and de novo design insights, aiming for roles that bridge academic teaching and computational drug-discovery projects.
6 years of coding experience
1 year of employment as a software developer
Doctor of Philosophy - PhD Chemical Biology, Doctor of Philosophy - PhD Chemical Biology at Tri-Institutional PhD Program in Chemical Biology (TPCB)Bachelor’s Degree Biology Chemistry, Bachelor’s Degree Biology Chemistry at The University of North Carolina at Chapel HillHigh School Diploma, High School Diploma at Delaware County Christian School
English, German
Github Skills (73)
computational-chemistry10
computational-biology10
molecular-dynamics-simulation10
simulation10
drug-discovery10
folding10
python9
evo9
machine-learning9
jupyter9
biophysics9
molecular-simulation9
algorithm9
science8
pdb-files8
Programming languages (9)
Github contributions (5)
choderalab/asapdiscovery-sars-retrospective
Jun 2023 - Aug 2025
Repository to store the code used for a paper exploring methods for SARS-2 Mpro Docking.
Contributions:33 PRs, 826 pushes, 40 branches in 2 years 2 months
choderalab/harbor
Feb 2024 - May 2026
A home for docking evaluation and assessment
Contributions:1 release, 12 PRs, 115 pushes in 2 years 3 months
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