Alexandra Lee

Staff ML Scientist at Mulholland

Philadelphia, Pennsylvania, United States
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Summary

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Senior
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Top School
Alexandra Lee is a Staff ML Scientist in Philadelphia with over a decade of computational research experience and 4+ years applying machine learning to biological problems. She specializes in unsupervised generative models for large-scale omics data, having developed influential tools like SOPHIE and the widely adopted ponyo package for simulating gene expression compendia. Her work spans end-to-end solutions—from engineering scalable ML workflows on UK Biobank multi-omic data to deploying NLP and LLM-driven tooling for product prioritization and user feedback analysis. Alexandra blends rigorous academic training (PhD in Genomics and Computational Biology, MS in Applied Mathematics) with practical product impact, enabling thousands of researchers through documentation, QA, and automated data-quality pipelines. Colleagues rely on her ability to surface subtle transcriptional signals that standard methods miss and to translate complex biological data into actionable insights.
code10 years of coding experience
job7 years of employment as a software developer
bookMaster of Science (MS) Applied Mathematics, Master of Science (MS) Applied Mathematics at University of Washington
bookBachelor of Arts (B.A.) Mathematics and Computer Science, Bachelor of Arts (B.A.) Mathematics and Computer Science at Bryn Mawr College
bookDoctor of Philosophy - PhD Genomics and Computational Biology, Doctor of Philosophy - PhD Genomics and Computational Biology at University of Pennsylvania
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Github Skills (88)

virus10
variants10
lda10
immunology10
chat10
gene-expression10
genomics10
computational-biology10
variational-autoencoder10
autoencoder10
biology10
bioinformatics10
simulate9
genes9
javascript9

Programming languages (9)

C++RCTeXSCSSJavaScriptHTMLJupyter Notebook

Github contributions (5)

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greenelab/ponyo

Jun 2020 - Jun 2022

Software to simulate compendium-wide gene expression data using a VAE.
Contributions:27 reviews, 35 commits, 51 PRs in 2 years
autoencoderdata-simulationcompendiumgene-expressionmachine-learning
Investigating the functional relationship between P. aeruginosa core and accessory genes.
Contributions:485 pushes, 108 branches in 2 years 4 months
relationshipbioinformaticsgenesaccessory
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Alexandra Lee - Staff ML Scientist at Mulholland