Andrew Marderstein

Research Fellow at Memorial Sloan Kettering Cancer Center

Palo Alto, California, United States
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Summary

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Andrew Marderstein is a computational human geneticist and research fellow with a decade of experience translating human genetics and multi-omic data into mechanistic insights and drug discovery leads. Currently at Memorial Sloan Kettering after a postdoc at Stanford and a PhD from Cornell/Weill, he combines statistical genetics, deep learning, and single-cell multi-omics to predict cell-type-specific regulatory effects and uncover chromatin-driven disease mechanisms. His work contributed to a Nature paper linking reshaped chromatin landscapes to clinical features of Down Syndrome and longstanding collaborations with industry (Pfizer, Third Rock Ventures) underline his translational focus. He has repeatedly built and applied novel methods—from vQTLs and GxE to single-cell regulatory models—to prioritize therapeutic targets and predict patient response. Based in Palo Alto, he pairs rigorous computational methods with consortium-scale leadership experience in projects like IGVF, bringing both academic depth and practical impact to precision medicine.
code10 years of coding experience
job2 years of employment as a software developer
bookDoctor of Philosophy - PhD Computational Biology & Medicine (CBM), Doctor of Philosophy - PhD Computational Biology & Medicine (CBM) at Weill Cornell Graduate School of Medical Sciences
bookBachelor of Science (BS) Biostatistics (Statistical Genomics concentration) Biological Sciences Minor, Bachelor of Science (BS) Biostatistics (Statistical Genomics concentration) Biological Sciences Minor at Cornell University
bookPostdoctoral Fellow - Computational Genomics, Postdoctoral Fellow - Computational Genomics at Stanford University
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2answers
6questions
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Github Skills (22)

markdown10
gitpod10
jekyll10
github-pages9
csv6
gam6
database6
cluster-computing6
bash6
forloop6
python6
bioinformatics5
tsne4
calculation4
calculator3

Programming languages (4)

RNextflowHTMLJupyter Notebook

Github contributions (5)

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drewmard/druggene

Jan 2021 - Jun 2021

Contributions:13 commits, 8 pushes in 4 months
drewmard/ukb_vqtl

Aug 2019 - Oct 2020

Contributions:159 commits, 15 pushes in 1 year 2 months
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Andrew Marderstein - Research Fellow at Memorial Sloan Kettering Cancer Center