Anthony Marcketta
Director, Computational Genomics
New York City Metropolitan Area United States
Summary
👤
Senior🎓
Top SchoolAnthony Marcketta is a Director of Computational Genomics with 12 years of experience blending computer science and genetics to build scalable, secure infrastructure for biobank-scale genomic analysis. He leads Production and Operations within an Analytical Genomics team at Regeneron, designing cloud-native, portable WDL/Docker pipelines and TRE-compliant workflows that process hundreds of thousands of samples and tens of millions of variants. A hands-on Python software engineer, he creates production-quality libraries, orchestration tooling, and reproducible workflows used by dozens of concurrent researchers. He mentors and manages bioinformatics teams, setting best practices for code quality, benchmarking, and tool adoption across cloud platforms like AWS and DNAnexus. An early contributor to the widely used vcftools project, he has deep low-level experience with VCF/BCF parsing and performance optimizations that inform his production pipeline designs. Based in the New York City area, he combines an academic grounding in genetics with pragmatic engineering to deliver compliant, efficient genomic analyses at scale.
12 years of coding experience
10 years of employment as a software developer
Masters of Business and Science Bioinformatics, Masters of Business and Science Bioinformatics at Rutgers | School of Graduate StudiesHigh School Diploma, High School Diploma at Hanover Park High SchoolBachelors Genetics and Computer Science, Bachelors Genetics and Computer Science at Rutgers University
Github Skills (10)
file-processing10
file-handling10
c-language10
file-access10
cprogramming-language10
fileio10
vcf-files10
bioinformatics9
memory-management9
algorithm7
Programming languages (2)
Github contributions (5)
vcftools/vcftools
Jun 2015 - Aug 2015
A set of tools written in Perl and C++ for working with VCF files, such as those generated by the 1000 Genomes Project.
Role in this project:
Back-end Developer
Back-end DeveloperContributions:2 releases, 13 commits, 1 PR in 1 month
Contributions summary:Anthony primarily contributed to the `vcftools/vcftools` repository by modifying C++ source code, specifically within the `cpp` directory, focused on handling VCF and BCF file formats. The commits show bug fixes related to BCF file conversions and memory management, improvements in BCF and VCF entry parsing, and optimization of BCF file interactions, including temporary file usage. They also updated header files and related code related to filters.
genomesvcf-filesperlvcf
amarcket/vcf_spec
Jul 2013 - Aug 2013
Contributions:3 commits in 14 days
specificationvariant-call-format
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