Blake Riley
Sr Scientist at Amgen
New York, New York, United States
Summary
👤
Senior🎓
Top SchoolBlake Riley is a senior scientist and computational structural biologist with 11 years’ experience applying protein modelling, design, and biophysical methods to enable therapeutics and drug discovery. He combines deep learning tools (AlphaFold, ProteinMPNN) with classical approaches (MD simulations, Rosetta, X-ray multi-conformer modelling) to probe links between protein evolution, dynamics and allostery. At Replay he led multi-project protein engineering efforts and commissioned HPC infrastructure, and his postdoctoral work produced qFit 3, a scientific software package for multiconformer crystallographic modelling. He holds a PhD in Biochemistry from Monash and dual undergraduate degrees in Chemical Engineering and Pharmaceutical Science, which inform a pragmatic, design-oriented approach to protein therapeutics. Blake has authored 19 peer-reviewed papers (7 as first/co-first author) and is based in New York, bringing both academic rigor and production-focused engineering to translational protein science. An under-the-radar strength is his hands-on experience spanning wet lab crystallography, software development and HPC administration, enabling end-to-end project delivery.
11 years of coding experience
8 years of employment as a software developer
VCE, English Language (Linguistics), Mathematical Methods CAS, Physics, Chemistry, French, Latin, ENTER 99.80, VCE, English Language (Linguistics), Mathematical Methods CAS, Physics, Chemistry, French, Latin, ENTER 99.80 at University High SchoolDoctor of Philosophy - PhD, Biochemistry and Molecular Biology, Doctor of Philosophy - PhD, Biochemistry and Molecular Biology at Monash University
English, French
Stackoverflow
1reputation
0reached
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Github Skills (53)
fst10
converter10
linuxbrew10
hpc-applications10
conformer10
bioinformatics10
table-of-contents9
markdown9
lzo9
tar9
ruby9
commonmark9
markup-language9
homebrew9
haskell9
Programming languages (8)
Github contributions (5)
blake-riley/homebrew-bio
Nov 2021 - Jul 2024
:beer::microscope: Bioinformatics formulae for the Homebrew package manager (macOS and Linux)
Contributions:1 PR, 10 pushes, 21 branches in 2 years 8 months
formulaemicroscopelinuxpackage-managerbioinformatics
blake-riley/update-checker
Nov 2021 - Dec 2025
Contributions:13 pushes, 1 branch in 4 years 1 month
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