Brad Holmes
Program Principal Engineer at National Center for Biotechnology Information (NCBI)
Rockville, Maryland, United States
Summary
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Rockstar🎓
Top SchoolBrad Holmes is a Program Principal Engineer with over a decade of experience designing and delivering highly scalable, performant systems for genomic data at NCBI. He co-leads the 100-person SeqPlus program and previously led the NCBI Datasets team that delivered 95 million data packages (600TB) and a widely used 12,000-line Golang CLI with over 500,000 downloads. His work spans migrating legacy platforms to GitLab and ArgoCD, building gRPC-backed microservices and reactive web frontends, and refactoring core services like dbSNP into MapReduce-backed, high-performance systems. A PhD-trained molecular biologist with a CS minor, he uniquely blends deep domain knowledge in biology with software engineering to rapidly turn scientific data into production-ready products. He is also an active mentor and architectural reviewer who drives team learning through code-a-thons, lunch-and-learns, and cross-functional collaboration.
10 years of coding experience
PhD, Molecular Biology, PhD, Molecular Biology at University of CambridgeB.S., Biochemistry, minor Computer Science, B.S., Biochemistry, minor Computer Science at Texas A&M University
Stackoverflow
36reputation
361reached
1answer
0questions
Github Skills (86)
python10
databases10
etl10
automation10
mlops10
rest-api10
genomics10
orchestration10
apache-airflow10
data-engineering10
ncbi10
scheduler10
api10
sdk10
rest10
Programming languages (8)
Github contributions (5)
conda-forge/ncbi-datasets-cli-feedstock
Aug 2021 - May 2026
A conda-smithy repository for ncbi-datasets-cli.
Contributions:4 reviews, 306 PRs, 22 pushes in 4 years 9 months
clicondancbi
ncbi/datasets
Apr 2020 - Jan 2023
NCBI Datasets is a new resource that lets you easily gather data from across NCBI databases.
Contributions:189 releases, 187 commits, 429 PRs in 2 years 9 months
databasedatabasesncbigenomics-data
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