Brad Holmes
Program Principal Engineer at National Center for Biotechnology Information (NCBI)
Rockville, Maryland, United States
Summary
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Rockstar🎓
Top SchoolBrad Holmes is a Program Principal Engineer with over a decade of experience designing and delivering highly scalable, performant systems for genomic data at NCBI. He co-leads the 100-person SeqPlus program and previously led the NCBI Datasets team that delivered 95 million data packages (600TB) and a widely used 12,000-line Golang CLI with over 500,000 downloads. His work spans migrating legacy platforms to GitLab and ArgoCD, building gRPC-backed microservices and reactive web frontends, and refactoring core services like dbSNP into MapReduce-backed, high-performance systems. A PhD-trained molecular biologist with a CS minor, he uniquely blends deep domain knowledge in biology with software engineering to rapidly turn scientific data into production-ready products. He is also an active mentor and architectural reviewer who drives team learning through code-a-thons, lunch-and-learns, and cross-functional collaboration.
10 years of coding experience
PhD, Molecular Biology, PhD, Molecular Biology at University of CambridgeB.S., Biochemistry, minor Computer Science, B.S., Biochemistry, minor Computer Science at Texas A&M University
Stackoverflow
36reputation
361reached
1answer
0questions
Github Skills (101)
python10
api-client10
datasets10
etl10
automation10
mlops10
pip10
rest-api10
genomics10
orchestration10
apache-airflow10
data-engineering10
ncbi10
scheduler10
starlark10
Programming languages (8)
Github contributions (5)
BradHolmes/datasets
Dec 2020 - Jan 2025
NCBI Datasets is an experimental resource for finding and building datasets
Contributions:8 pushes, 3 branches in 4 years 1 month
datasetsfindingdatasetncbi
BradHolmes/ncbi-datasets-cli-feedstock
Aug 2021 - Mar 2025
A conda-smithy repository for ncbi-datasets-cli.
Contributions:2 PRs, 37 pushes, 228 branches in 3 years 7 months
pythoncondancbismithydataset
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