CharlesĀ Markello
Senior Bioinformatics Engineer
San Diego, California, United States
Summary
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Top SchoolCharles Markello is a Senior Bioinformatics Engineer with 11 years of experience building and shipping genomic analysis software and production pipelines for both research and clinical applications. He has driven feature development and CI/CD improvements at Illumina, developed scalable phasing and population reference pipelines, and is now applying that expertise at Diploid Genomics to improve sequencing accuracy and diagnostic utility. With a PhD in Biomolecular Engineering and hands-on experience refining pangenome graph mappers and coordinating model training with industry partners, he combines deep algorithmic insight with practical software engineering. Known for cutting through complexity quickly, he favors pragmatic pruning of low-value features to improve maintainability and customer impact. Based in San Diego, he is particularly focused on rare-disease and clinical genomics projects that translate sequence data into actionable medical knowledge.
11 years of coding experience
10 years of employment as a software developer
BS, Computer Science with Biology minor, BS, Computer Science with Biology minor at University of OregonUniversity of California Santa Cruz
English
Github Skills (62)
genome10
exchange10
portal10
genomics10
scripting9
slurm9
gridengine9
distributed-computing9
graph9
common-workflow-language9
aws9
pipeline9
bioinformatics9
pure-python9
needle9
Programming languages (9)
Github contributions (5)
cmarkello/muts-needle-plot
Nov 2015 - Aug 2017
A needle plot for mutation data
Contributions:1 PR, 143 pushes, 3 branches in 1 year 9 months
plotmutationmutation-dataneedle
cmarkello/vg-pedigree-paper
Oct 2021 - Mar 2022
Contributions:9 commits, 7 pushes, 1 branch in 4 months
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