Charlie Li
Associate Director
Pennsylvania, United States
Summary
🤩
Rockstar🎓
Top SchoolCharlie Li is an Associate Director and molecular biologist with 12 years of cross-sector experience bridging academic gene discovery and industrial assay development for gene therapies and GMP biomanufacturing. He led discovery of TBX5 linked to Holt-Oram syndrome and now directs molecular assay R&D and outsourcing as SME at Spark Therapeutics, supporting clinical and nonclinical programs including AAV gene therapies. His background spans postdoctoral genomics and virology, rapid genetic testing, NGS and Oxford Nanopore applications, and validated PCR diagnostics for GMP use, with multiple conference presentations and patents. Unusually for a biomedical scientist, he also contributes to open-source infrastructure and tooling—making backend and packaging improvements to projects like FreeBSD poudriere and CHIRP—demonstrating a pragmatic fluency in reproducible automation and DevOps.
12 years of coding experience
14 years of employment as a software developer
Postdoctoral Fellow Sponsored by UK-MRC Human Genome Program and British Heart Foundation Human Molecular Genetics & Genomics, Postdoctoral Fellow Sponsored by UK-MRC Human Genome Program and British Heart Foundation Human Molecular Genetics & Genomics at University of NottinghamPostdoctoral Fellow Sponsored by UK-MRC AIDS Directed Program Molecular Virology, Postdoctoral Fellow Sponsored by UK-MRC AIDS Directed Program Molecular Virology at University of Reading
English, Chinese
Github Skills (22)
package-management10
python10
scripting10
freebsd10
build-system10
libressl10
script10
openssl10
wxpython10
cryptography10
build-automation10
sh10
rust10
shell10
python-packaging9
Programming languages (11)
Github contributions (5)
rust-openssl/rust-openssl
Sep 2018 - Dec 2022
OpenSSL bindings for Rust
Role in this project:
Back-end Developer
Back-end DeveloperContributions:4 reviews, 59 commits, 16 PRs in 4 years 3 months
Contributions summary:Charlie primarily contributed to the `rust-openssl` repository by supporting various versions of LibreSSL. Their work involved modifying build scripts and configuration files to ensure compatibility with different LibreSSL releases, including the addition of new features and security updates. They also addressed function signature changes and updated the library's dependencies. Their contributions focused on maintaining and expanding the library's support for different OpenSSL/LibreSSL versions.
opensslrust
kk7ds/chirp
Dec 2022 - Dec 2022
Official git repo for the CHIRP project
Role in this project:Full-stack Developer
Full-stack DeveloperContributions:11 reviews, 10 commits, 4 PRs in 22 days
Contributions summary:Charlie made multiple contributions to the CHIRP project, focusing on modernizing the codebase and improving packaging. They refactored the code to use `importlib_resources` for loading data files, ensuring proper inclusion in binary distributions and bumped the minimum Python version. They also fixed packaging dependencies and test paths. The user's work spanned both the UI and backend components, as evidenced by changes to setup.py, and various Python modules.
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