Christopher Nobles
Lead Bioinformatician
Baltimore, Maryland, United States
Summary
👤
Senior🎓
Top SchoolChristopher Nobles is a Lead Bioinformatician with 11 years of experience designing and scaling computational biology solutions for oncology diagnostics, gene and cell therapies, and genomic engineering. He has led development of NGS-based assays and cloud-native pipelines that improved sensitivity, specificity, and scalability for multi-cancer early detection and aneuploidy detection. His work spans algorithm development (contamination estimation, copy-number and methylation analyses), ML model design, and practical assay translation from feasibility to validated clinical workflows. Christopher has driven cross-functional programs at Exact Sciences and Natera and advised clients as an independent consultant on biomarker discovery and study design. He combines deep wet-lab collaboration experience from academic gene therapy projects with a track record of converting novel analytics into production-ready pipelines intended for millions of samples. Notably, he developed widely applied integration-site and QC utilities used across gene therapy and CART product evaluations.
11 years of coding experience
10 years of employment as a software developer
Doctor of Philosophy (Ph.D.) Molecular Virology and Microbiology, Doctor of Philosophy (Ph.D.) Molecular Virology and Microbiology at Baylor College of MedicineB.S. Biochemical and Chemical Engineering, B.S. Biochemical and Chemical Engineering at Colorado School of MinesPostdoctoral Researcher Microbiology Virology Gene and Cell Therapy, Postdoctoral Researcher Microbiology Virology Gene and Cell Therapy at University of Pennsylvania
Github Skills (14)
designer10
marker10
genomics9
bioinformatics9
rna-seq9
pipeline8
forking4
cloning3
r-programming3
sequence-analysis2
react2
volumes2
sequence2
programming-language1
Programming languages (1)
Github contributions (5)
BushmanLab/simIntSiteReads
Sep 2015 - Dec 2017
Contributions:4 PRs, 2 pushes, 1 branch in 2 years 3 months
BushmanLab/genomicHeatmapMaker
Jun 2015 - Jul 2019
Contributions:1 PR, 7 pushes, 1 branch in 4 years 1 month
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