David Cluet
Research Engineer 1rst Class at CNRS - Centre national de la recherche scientifique
Lyon, Auvergne-Rhône-Alpes, France
Summary
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Senior🎓
Top SchoolDavid Cluet is a Research Engineer with over two decades of hands-on experience probing protein-protein interactions, combining deep molecular biology expertise with practical programming to turn complex experimental workflows into reproducible, automated analyses. Based at CNRS in Lyon, he developed and optimized assays (BRET, cross-linked co-IP, enhanced Y2H) and applied them to diverse biological problems from HIV-1 Nef–mediated CD4 downregulation to peptide aptamers that modulate apoptosis and muscle regeneration. His PhD in molecular retrovirology and engineering background underpin a rare blend of wet-lab rigor and object-oriented software development—one resulting tool even secured a patent. He leads integrative projects end-to-end, from expression cassette design through unbiased data processing, enabling cross-disciplinary collaborations and more sensitive detection of interaction determinants such as residues, PTMs, and mutations. Colleagues benefit from his methodical approach to quantification and his focus on making complex PPI data actionable for disease-focused research.
8 years of coding experience
PhD - Molecular Retrovirology, Study of the HIV-1 Nef accessory protein, PhD - Molecular Retrovirology, Study of the HIV-1 Nef accessory protein at Université de StrasbourgIngeneer, Cell/Cellular and Molecular Biology, Ingeneer, Cell/Cellular and Molecular Biology at École Supérieure de Biotechnologie de Strasbourg
English, German, FrenchProgramming languages (1)
Github contributions (5)
dcluet/NUKE-BREAK
Mar 2018 - May 2018
Contributions:8 commits, 1 push, 1 branch in 2 months
dcluet/qY2H-Affinity-Ladder
Nov 2018 - Jul 2019
Contributions:8 pushes, 2 branches in 8 months
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