Dominique Sydow

Cheminformatics Research Scientist 3

United Kingdom
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Summary

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Senior
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Dominique Sydow is a cheminformatics and structural bioinformatics scientist with nine years of experience applying data-driven methods to guide drug discovery decisions. Currently a Cheminformatics Research Scientist at Recursion, Dominique has held progressive research roles at Exscientia, Sosei Heptares and academic labs where they developed kinase-focused tools like KiSSim and KinFragLib during a PhD at Charité. They contribute to the TeachOpenCADD open-source teaching platform and have improved widely used tools such as BioPandas by enhancing PDB handling, unit tests, and robust error reporting. Skilled in mining chemical, structural, and pharmacological datasets, Dominique blends software engineering with domain expertise to translate complex molecular data into actionable insights. Known for pragmatic code improvements and reproducible workflows, they bridge academic rigor and industry-scale cheminformatics practice.
code9 years of coding experience
job8 years of employment as a software developer
bookDoctoral candidate Structural Bio/Cheminformatics, Doctoral candidate Structural Bio/Cheminformatics at Freie Universität Berlin
bookMaster's degree Biophysics, Master's degree Biophysics at Humboldt-Universität zu Berlin
bookBachelor's degree Molecular Life Science, Bachelor's degree Molecular Life Science at Universität zu Lübeck
languagesEnglish, German, French
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Github Skills (7)

bioinformatics10
pandas10
pdb10
python10
pytest9
unit-testing9
computational-biology7

Programming languages (8)

TypeScriptPromelaC++CSSJavaScriptHTMLJupyter NotebookPython

Github contributions (5)

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BioPandas/biopandas

Oct 2020 - Oct 2020

Working with molecular structures in pandas DataFrames
Role in this project:
userBack-end Developer
Contributions:6 commits, 2 PRs, 7 comments in 8 days
Contributions summary:Dominique focused on enhancing the `biopandas` library, specifically improving the handling of PDB files. They implemented a method to read PDB files from a list and added unit tests. Furthermore, they improved error handling by raising exceptions for incorrect file formats and when no atoms are loaded. They also refined the code by removing whitespace and ensuring the correct handling of mol2 format files.
pythonpdbmoleculebioinformaticsdataframes
volkamerlab/KinFragLib

Feb 2020 - Oct 2022

Kinase-focused fragment library
Contributions:2 releases, 2 reviews, 309 commits in 2 years 8 months
fragmentfocusedkinase
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