Honglue Shi
NIH K99 R00 Pathway To Independency Awardee (NIGMS)
Berkeley, California, United States
Summary
👤
Senior🎓
Top SchoolHonglue Shi is an award-winning structural biophysicist and NIH K99/R00 Pathway to Independence awardee based in Berkeley, focused on revealing how DNA and RNA dynamics drive function and disease. Trained in Duke’s Al-Hashimi lab and now working with Jennifer Doudna, Honglue develops and integrates NMR, quantum mechanics calculations, and 3D modeling to image nucleic acid conformational ensembles at atomic resolution. Their work bridges single-molecule structural physics and large ribonucleoprotein complexes, with plans to incorporate cryo-EM to tackle systems beyond conventional NMR limits. With a PhD in Chemistry, an MS in Computer Science, and nine years of research experience, they uniquely combine computational rigor and experimental biophysics to make predictions about molecular recognition. Honglue aims to translate fundamental insights into RNA-targeting small-molecule therapeutics for diseases from AIDS to COVID-19, reflecting both basic-science curiosity and translational ambition. A subtle strength is their interdisciplinary fluency—melding quantum calculations, biophysical measurements, and computational modeling—to probe the unseen, short-lived states that govern nucleic acid biology.
9 years of coding experience
8 years of employment as a software developer
Doctor of Philosophy - PhD, Chemistry, Doctor of Philosophy - PhD, Chemistry at Duke UniversityBachelor of Science - BS, Chemistry, Bachelor of Science - BS, Chemistry at Peking University
Chinese, English
Github Skills (9)
genome5
interpretation5
rna-seq5
bioinformatics4
sequencing4
genomics3
pipeline3
editing3
rapid2
Programming languages (1)
Github contributions (5)
lvelve0901/TF_MM
Jun 2020 - Aug 2020
Contributions:5 commits, 3 pushes, 1 branch in 2 months
lvelve0901/myLeetCode
May 2017 - Feb 2018
Contributions:2 pushes, 1 branch in 8 months
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