Jake Lehle
Postdoctoral Researcher at Texas Biomedical Research Institute
San Antonio, Texas, United States
Summary
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Rockstar🎓
Top SchoolJake Lehle is a postdoctoral researcher and molecular biologist with a PhD focused on how epigenetic changes shape and persist in cell identity, combining 5+ years of wet-lab work with 3+ years of NGS data generation and analysis. His doctoral work developed in vitro systems to reveal cell type–specific susceptibilities to endocrine-disrupting chemical–induced epimutations and traced their persistence through cell fate transitions, leading to a manuscript submitted to eLife. Now studying host–pathogen interactions and spermatogonial stem cell epigenetics at Texas Biomedical Research Institute and UTSA, he integrates single-cell RNA-seq, bulk RNA-seq and ChIP-seq to define transcriptional and epigenetic programs. Known for both experimental rigor and bioinformatics tooling—he authored a faster DNA methylation analysis pipeline—Jake blends mechanistic curiosity with practical pipeline improvements that accelerate reproducible genomics research.
4 years of coding experience
12 years of employment as a software developer
University of Texas at San Antonio
Stackoverflow
1reputation
0reached
0answers
0questions
Github Skills (60)
package-management10
conda10
transcriptomics10
single-cell-analysis10
bioinformatics10
bioconda10
scanpy10
nmf9
python9
machine-learning9
scales9
genome9
seq9
biodiversity9
genomics8
Programming languages (7)
Github contributions (5)
JakeLehle/gemBS
Jan 2022 - Jan 2022
gemBS is a bioinformatics pipeline designed for high throughput analysis of DNA methylation from Whole Genome Bisulfite Sequencing data (WGBS).
Contributions:4 releases, 6 PRs, 211 pushes in 21 days
genomewgbspipelinebisulfite-sequencingdna
JakeLehle/bioconda-recipes
Jan 2022 - Feb 2024
Conda recipes for the bioconda channel.
Contributions:2 PRs, 125 pushes, 6 branches in 2 years 2 months
biocondabioinformaticsrecipesconda
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