Josh Perfetto is a serial founder and engineering-focused CEO with 16 years of experience building biotech and climate-tech ventures from the lab bench to the market. Based in the San Francisco Bay Area, he currently leads Sempera, developing engineered microbial therapeutics for human longevity after founding Ephemeral Carbon (ocean-based CO₂ removal) and Chai (molecular diagnostics). His career blends deep hands-on product engineering—dating back to creating visual voicemail and early mobile video services—with a passion for democratizing biotech, co-creating OpenPCR and cofounding the world’s first biohackerspace, BioCurious. He repeatedly bridges hardware, wet lab, and software disciplines to ship practical, scalable systems that tackle long-term planetary and human health problems. Columba and RIT-trained in computer science, he combines entrepreneurial grit with a maker’s ethos and a willingness to take bold risks, evident in his move from consumer mobile innovations to high-impact bioscience and carbon removal startups.
16 years of coding experience
16 years of employment as a software developer
BS Computer Science, BS Computer Science at Rochester Institute of Technology
Computer Science, Computer Science at Columbia University
The software behind Chai's open-source Real-Time PCR instrument
Contributions:358 commits, 4 PRs, 109 pushes in 7 years 1 month
pcrpythonbiotechnologyc-plus-plusbioinformatics
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