Jui-hua Hsieh
Staff Scientist at National Institute of Environmental Health Sciences (NIEHS)
Durham, North Carolina, United States
Summary
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Senior🎓
Top SchoolJui-hua Hsieh is a Staff Scientist with 12 years of experience specializing in structure- and ligand-based drug design, cheminformatics, and computational toxicology, currently based at NIEHS in Durham, NC. She combines deep technical skills—docking, homology modeling, pharmacophore modeling, QSAR, clustering, and machine learning—with practical knowledge of in vitro HTS and virtual screening workflows. Her work blends bioinformatics (R/Bioconductor for gene selection and pathway enrichment) with medicinal chemistry and pharmacology to interpret assay hits and prioritize compounds for toxicity testing. She has a strong track record of developing novel cheminformatics methods, including pose filters and DFT-based interfacial descriptors, that improved virtual screening enrichment and binding-affinity modeling. Notably, she has translated qHTS statistical approaches into hit-ranking systems and predictive toxicity models used to inform rat acute toxicity testing. Trained with a PhD from UNC Chapel Hill and a BS in Pharmacy from National Taiwan University, she bridges academic rigor and applied regulatory science.
12 years of coding experience
11 years of employment as a software developer
BS, Pharmacy, BS, Pharmacy at National Taiwan UniversityDoctor of Philosophy (Ph.D.), Pharmaceutical Sciences, Doctor of Philosophy (Ph.D.), Pharmaceutical Sciences at University of North Carolina at Chapel Hill
Chinese
Stackoverflow
405reputation
158kreached
2answers
2questions
Github Skills (16)
r-package7
html6
rmarkdown6
markdown6
ggplot6
explore6
r6
plotly6
rjava6
java6
shiny5
data-storage4
modeling4
profiling3
dropbox2
Programming languages (3)
Github contributions (5)
moggces/CurveVisualizationGUI4Tox21
Jan 2015 - Jun 2019
Contributions:1 release, 17 pushes, 2 branches in 4 years 5 months
visualizeshinycollaborationshiny-rconcentration-response
moggces/ActivityProfilingGUI
Mar 2014 - Mar 2017
Contributions:61 commits, 4 PRs, 27 pushes in 3 years
profilingexploreshinyrstatsshiny-r
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