Luca Pinello
Boston, Massachusetts, United States
Summary
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RockstarLuca Pinello is a computational biologist and associate professor at MGH/Harvard who blends machine learning, single-cell genomics, CRISPR genome editing, and generative AI to tackle gene regulation and disease. He leads a lab that produces widely used open-source tools (CRISPResso2, CRISPRme, PrimeDesign, BEAN) and novel methods for single-cell trajectory and multimodal analysis (STREAM, Dictys, SIMBA), and his work has informed regulatory discussions around CRISPR therapies. As an associate member of the Broad Institute’s Gene Regulatory Observatory and an affiliate of the Kempner Institute, he directs large-scale functional genomics efforts within the NIH IGVF Consortium, applying base editing to dissect variant effects in heart and blood disease. His recent research extends to DNA-Diffusion, a diffusion-model approach for designing cell-type-specific regulatory sequences with therapeutic potential, reflecting a rare combination of rigorous mathematics, software engineering, and experimental collaboration. Based in Boston with 14 years of experience, he also co-founded Edilytics and trains the next generation as course co-director in computational biology at Harvard.
15 years of coding experience
Github Skills (118)
plotly-dash10
python10
package-management10
diffusion-models10
differentiation10
charting10
genomics10
flask10
artisan10
single-cell-analysis10
rna-seq10
bioconda10
plotly10
jupyter10
finance10
Programming languages (10)
Github contributions (5)
lucapinello/bioutilities
Sep 2011 - Jun 2016
Contributions:101 commits, 23 pushes in 4 years 9 months
lucapinello/Haystack
Aug 2014 - Oct 2017
Epigenetic Variability and Transcription Factor Motifs Analysis Pipeline
Contributions:125 commits, 3 PRs, 65 pushes in 3 years 2 months
analysis-pipelinepipelinemotifstranscriptionfactor
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