Summary
Mark Holt is a Director of Bio-Data Science with 11 years in medical device analytics and a prior career as a practicing medical doctor, holding a PhD in Information Engineering focused on neural networks. He designs small-footprint, firmware-ready ML algorithms and has shipped multiple FDA-approved embedded algorithms for respiratory rate and pulse quality, sleep detection, and wearable state detection. His expertise spans biomedical signal processing (ECG, EEG, PPG, accelerometry, force-sensor respiration), classical and deep learning methods, and production tooling in Python, C, TensorFlow and AWS. At Spire Health he translates continuous respiration sensing into clinically actionable insights and is developing personalized COPD exacerbation prediction and breath-level metrics. Combining clinician training, deep algorithmic rigor, and hands-on firmware experience, he uniquely bridges bedside physiology and constrained embedded systems. An early entrepreneur and former CTO/COO-level operator, he also brings product, regulatory validation and sysadmin chops to data-driven medical product development.
11 years of coding experience
19 years of employment as a software developer
Bachelor of Medicine, Bachelor of Surgery (MBBS), Bachelor of Medicine, Bachelor of Surgery (MBBS) at The University of Western Australia
General Assembly
PhD, Information Engineering, PhD, Information Engineering at University of Oxford