Matthew Wilhelm
Scientist II, Biologic Drug Substance Development at Alexion Pharmaceuticals, Inc.
Hamden, United States
Summary
👤
Senior🎓
Top SchoolMatthew Wilhelm is a chemical engineer and Scientist II in Biologic Drug Substance Development with nine years of experience bridging process engineering, pilot-scale manufacturing, and advanced process modeling. He specializes in reduced-space global optimization for complex dynamical systems, blending physics-based models with machine learning surrogates and delivering open-source tools that operationalize those methods. His work spans industry and academia—from Corning process scale-up and two patents to doctoral research producing theoretical advances for MINLPs/SIPs and multiple publications. Known for translating sophisticated optimization theory into practical cost-saving solutions, he has driven multi-million-dollar impact while mentoring junior engineers and contributing reproducible software for challenging simulation-driven problems.
9 years of coding experience
13 years of employment as a software developer
Certificate in, Central European Studies Program, Certificate in, Central European Studies Program at Masarykova univerzita Právnická fakultaMaster of Science, Chemical Engineering, Master of Science, Chemical Engineering at Columbia University - Fu Foundation School of Engineering and Applied ScienceDoctor of Philosophy (Ph.D.), Chemical Engineering, Doctor of Philosophy (Ph.D.), Chemical Engineering at University of ConnecticutBachelor of Science, Applied Mathematics, Minor in Chemistry, Bachelor of Science, Applied Mathematics, Minor in Chemistry at University of North Carolina at Greensboro
Github Skills (81)
optimization10
optimization-methods10
optimizer10
integer10
julia10
development-environment10
mixed-integer-programming10
nonlinear9
interval-arithmetic9
stochastic-processes9
ipopt9
linear-optimization9
inverse9
solver9
mathematical9
Programming languages (2)
Github contributions (5)
PSORLab/McCormick.jl
Mar 2020 - Sep 2022
Contributions:17 releases, 382 commits, 14 PRs in 2 years 6 months
forwardoptimization-toolsoperatorjulia
PSORLab/DynamicBounds.jl
May 2020 - Mar 2022
Bounds and Relaxations of Parametric Differential Equations
Contributions:4 PRs, 30 pushes, 4 comments in 1 year 10 months
equationsparametricdynamical-systemsboundsdifferential
Find and Hire Top DevelopersWe’ve analyzed the programming source code of over 60 million software developers on GitHub and scored them by 50,000 skills. Sign-up on Prog,AI to search for software developers.