Principal Scientific Software Engineer at Genentech
San Francisco, California, United States
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Summary
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Sébastien Lelong is a Principal Scientific Software Engineer with 12+ years building high-throughput, cloud-native backend systems for biotech and finance, currently designing Genentech’s ArtifactDB to make genomics datasets reliably available as self-service data products. He brings deep Python expertise in concurrent programming, API design and network protocols, and has a strong track record architecting scalable AWS solutions (S3, EKS, RDS, DynamoDB, OpenSearch, IAM) with CI/CD and IaC. Previously he led Biothings APIs at Scripps, optimizing pipelines from multi-week to hourly runs and enabling public, highly-trafficked bioinformatics services that process billions of documents. Equally comfortable in systems, databases (MySQL, MongoDB, Elasticsearch) and operations, he has driven migrations to cloud, automated deployments, and built developer-facing platforms to increase contributions and reproducibility. Known for pragmatic automation and data-first design, he often combines research-minded ML prototyping with production-grade engineering to surface non-obvious bottlenecks and scale distributed data workloads.
12 years of coding experience
15 years of employment as a software developer
DESS Genie Biologique Informatique, Biomathematics, Bioinformatics, and Computational Biology, DESS Genie Biologique Informatique, Biomathematics, Bioinformatics, and Computational Biology at Université d'Evry-Val d'Essonne
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Sébastien Lelong - Principal Scientific Software Engineer at Genentech