Shayna Simonstein
Principal Scientist at Frontier Medicines
Boston, Massachusetts, United States
Summary
👤
Senior🎓
Top SchoolShayna Simonstein is a Principal Scientist and computational biologist in Boston with 10 years of experience applying statistical and machine learning methods to cancer biology and drug discovery. With a PhD in Biostatistics and a background in applied math, she builds predictive models and quantitative pipelines for sequencing, proteomics, and chromatin datasets while partnering closely with wet lab teams. Her work spans academic modeling of tumor evolution and clinical translational projects, including PK/PD integration and mechanism-focused modeling of CDK inhibitors. Uncommonly for a computational scientist, she has hands-on experience developing mouse-derived organoid models, enabling her to bridge experimental design and computational analysis end-to-end. At Frontier Medicines and prior companies she has led biomarker and patient-selection hypothesis generation, and she’s published and presented modeling and tumor-evolution studies from her Harvard doctoral work.
10 years of coding experience
8 years of employment as a software developer
High School Diploma, High School Diploma at Torrey Pines High SchoolDoctor of Philosophy (Ph.D.), Biostatistics, Doctor of Philosophy (Ph.D.), Biostatistics at Harvard UniversityUniversity of California, Los Angeles
American Sign Language
Github Skills (12)
cancer-genomics9
genomics8
bioinformatics8
ggplot8
science7
htmlwidgets7
visualization7
r4
rna-seq3
ssa3
yang3
jack2
Programming languages (2)
Github contributions (5)
Xinglab/rPGA
Sep 2015 - Jun 2016
Contributions:108 commits, 104 pushes, 2 comments in 8 months
sstein93/git-github-workshop
Mar 2025 - Mar 2025
Contributions:2 PRs, 41 pushes, 2 branches in 5 days
Find and Hire Top DevelopersWe’ve analyzed the programming source code of over 60 million software developers on GitHub and scored them by 50,000 skills. Sign-up on Prog,AI to search for software developers.