Thyago Leal-calvo
Pesquisador at Ciência Pioneira
São Paulo, Brazil
Summary
👤
Senior🎓
Top SchoolThyago Leal-Calvo is a molecular biologist and bioinformatician with nine years of experience developing CRISPR and epigenetic editing approaches for neurological disease therapeutics, currently working on Alzheimer’s epigenetic editing through a joint IGI/IDOR initiative sponsored by Ciência Pioneira. He combines hands-on gene editing (CRISPR/Cas9, zinc-finger nucleases) with computational strengths in R, Python, Shell and SQL to drive sequence analysis, biomarker discovery and experimental design. His background spans academia and industry—from FIOCRUZ doctoral research and a postdoc at the Innovative Genomics Institute to technical consulting for bioinformatics platforms—giving him a pragmatic view of translational pipeline challenges. Thyago also applies advanced statistics and simulation (linear mixed models, ML classifiers, Monte Carlo power analysis) to strengthen reproducibility and trial readiness, and he leverages CRISPR not only to correct variants but to build better disease models and mechanistic insight.
9 years of coding experience
Bacharelado, Biology/Biological Sciences, General, Bacharelado, Biology/Biological Sciences, General at Universidade Federal de GoiásDoutorado, Biologia Molecular e Bioinformática, Doutorado, Biologia Molecular e Bioinformática at FIOCRUZ - Fundação Oswaldo Cruz
English, Portuguese, Spanish
Github Skills (39)
single-cell-genomics9
citations9
cran9
creative-commons8
bibliography8
css8
csl8
standardized7
meta-analysis7
citation7
interpretation7
data-storage6
correlation6
seq6
visualize6
Programming languages (6)
Github contributions (5)
thyagoleal/land_page
Feb 2021 - Mar 2026
Contributions:83 pushes, 1 branch in 5 years 1 month
thyagoleal/thyagoleal.github.io
Feb 2021 - Mar 2026
Contributions:73 pushes, 1 branch in 5 years 1 month
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