Thyago Leal-calvo
Pesquisador at Ciência Pioneira
São Paulo, Brazil
Summary
👤
Senior🎓
Top SchoolThyago Leal-Calvo is a molecular biologist and bioinformatician with nine years of experience developing CRISPR and epigenetic editing approaches for neurological disease therapeutics, currently working on Alzheimer’s epigenetic editing through a joint IGI/IDOR initiative sponsored by Ciência Pioneira. He combines hands-on gene editing (CRISPR/Cas9, zinc-finger nucleases) with computational strengths in R, Python, Shell and SQL to drive sequence analysis, biomarker discovery and experimental design. His background spans academia and industry—from FIOCRUZ doctoral research and a postdoc at the Innovative Genomics Institute to technical consulting for bioinformatics platforms—giving him a pragmatic view of translational pipeline challenges. Thyago also applies advanced statistics and simulation (linear mixed models, ML classifiers, Monte Carlo power analysis) to strengthen reproducibility and trial readiness, and he leverages CRISPR not only to correct variants but to build better disease models and mechanistic insight.
9 years of coding experience
Bacharelado, Biology/Biological Sciences, General, Bacharelado, Biology/Biological Sciences, General at Universidade Federal de GoiásDoutorado, Biologia Molecular e Bioinformática, Doutorado, Biologia Molecular e Bioinformática at FIOCRUZ - Fundação Oswaldo Cruz
English, Portuguese, Spanish
Github Skills (56)
styles10
single-cell-genomics9
citations9
csl9
bioinformatics9
cran9
genomics9
creative-commons9
citation8
bibliography8
css8
anova7
correlation7
interpretation7
meta-analysis6
Programming languages (7)
Github contributions (5)
thyagoleal/land_page
Feb 2021 - Feb 2025
Contributions:74 pushes, 1 branch in 4 years
thyagoleal/leprosy_reanalysis_paper
Mar 2018 - Jan 2023
Contributions:45 commits, 11 pushes in 4 years 10 months
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