Tristan Croll
Principal Scientist at Altos Labs
Cambridge, England, United Kingdom
Summary
👤
Senior🎓
Top SchoolTristan Croll is a Principal Scientist and computational structural biologist with eight years of focused experience building GPU-accelerated, physics-based tools for cryo-EM and X-ray crystallographic model refinement. Based in Cambridge and currently at Altos Labs after a research appointment at the University of Cambridge, he develops ISOLDE—an immersive environment that makes growing atomic models behave like real molecules while providing continuous real-time validation. His work bridges software engineering and molecular physics to rescue ambiguous or low-resolution experimental maps, reducing rebuild cycles and improving downstream ligand-design confidence. A former chemical engineer turned structural biology methods developer with a PhD in tissue engineering, he combines rigorous academic training and practical consultancy for time-sensitive, high-stakes model-building cases. Tristan’s approach is notable for integrating interactive molecular dynamics with immediate geometric error highlighting, making model correction both intuitive and scientifically robust.
9 years of coding experience
6 years of employment as a software developer
Bachelor's degree, Chemical Engineering, Hons I, Bachelor's degree, Chemical Engineering, Hons I at The University of QueenslandThe University of Melbourne
Github Skills (59)
simulation10
graph-algorithms10
hierarchical10
molecular-simulation10
computational-science10
folding10
structural-biology10
dynamics10
model-building10
crystallography10
graph-visualization10
bioinformatics10
simulator9
atom-editor9
graph-analysis9
Programming languages (6)
Github contributions (5)
tristanic/isolde
Aug 2017 - Jan 2023
Interactive molecular dynamics based model building into low-resolution crystallographic and cryo-EM maps
Contributions:3 reviews, 812 commits, 5 PRs in 5 years 6 months
model-basedcryo-emmolecular-dynamicschemoinformaticsresolution
tristanic/chimerax-clipper
May 2019 - Dec 2022
Contributions:142 commits, 281 pushes, 9 branches in 3 years 7 months
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