Tristan Croll
Principal Scientist at Altos Labs
Cambridge, England, United Kingdom
Summary
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Senior🎓
Top SchoolTristan Croll is a Principal Scientist and computational structural biologist with eight years of focused experience building GPU-accelerated, physics-based tools for cryo-EM and X-ray crystallographic model refinement. Based in Cambridge and currently at Altos Labs after a research appointment at the University of Cambridge, he develops ISOLDE—an immersive environment that makes growing atomic models behave like real molecules while providing continuous real-time validation. His work bridges software engineering and molecular physics to rescue ambiguous or low-resolution experimental maps, reducing rebuild cycles and improving downstream ligand-design confidence. A former chemical engineer turned structural biology methods developer with a PhD in tissue engineering, he combines rigorous academic training and practical consultancy for time-sensitive, high-stakes model-building cases. Tristan’s approach is notable for integrating interactive molecular dynamics with immediate geometric error highlighting, making model correction both intuitive and scientifically robust.
8 years of coding experience
6 years of employment as a software developer
Bachelor's degree, Chemical Engineering, Hons I, Bachelor's degree, Chemical Engineering, Hons I at The University of QueenslandThe University of Melbourne
Github Skills (90)
graph-algorithms10
crystallography10
graph-visualization10
graph-theory10
structural-biology10
high-performance10
molecular-simulation10
dynamics10
model-building10
cuda10
simulation10
hierarchical10
folding10
topology10
bioinformatics10
Programming languages (5)
Github contributions (5)
tristanic/pae_to_domains
Aug 2021 - Jul 2022
Contributions:9 commits, 1 PR, 6 pushes in 11 months
community-basedgraph-basedautoencoderapproachgraph-neural-network
tristanic/isolde
Aug 2017 - Jan 2023
Interactive molecular dynamics based model building into low-resolution crystallographic and cryo-EM maps
Contributions:812 commits, 3 PRs, 390 pushes in 5 years 6 months
model-basedcryo-emmolecular-dynamicschemoinformaticsresolution
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