Wen Yu
Principal Scientist at AstraZeneca
Gaithersburg, Maryland, United States
Summary
👤
Senior🎓
Top SchoolWen Yu is a Principal Scientist and computational biologist with 11+ years in industry-focused biomarker analytics, currently driving translational bioinformatics at AstraZeneca. He combines deep mass-spectrometry and genomics experience with full-stack data science—QC, statistical modeling, informatics, and visualization—to inform early-phase clinical decisions in inflammation and oncology. Wen built company-wide proteomics platforms and novel MS/MS search engines that improved peptide ID sensitivity and supported quantitative assay design, and he has applied hierarchical clustering, PCA, GLMs and pathway/network analysis to pharmacodynamic and stratification biomarkers. Equally comfortable writing probabilistic scoring models and database-backed visualization tools, he has a rare mix of hands-on algorithm development and practical assay qualification experience. Based in Gaithersburg, MD, Wen’s work is notable for translating complex spectral and omics signal into robust clinical-grade biomarkers.
11 years of coding experience
24 years of employment as a software developer
Master Chemistry, Master Chemistry at University of Houston
Github Skills (46)
command-line-interface9
mass-spectrometry9
igraph9
heatmap9
shiny8
metric8
r-package8
semantic-similarity7
r7
threejs7
drag-and-drop7
openms6
ptx6
rstudio6
web-development5
Programming languages (10)
Github contributions (5)
wyu/ms2ms
Jul 2015 - Oct 2022
Contributions:1 release, 295 pushes, 1 branch in 7 years 4 months
wyu/molgraph
Jan 2015 - Aug 2015
Contributions:47 commits, 17 pushes, 1 issue in 7 months
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