William Hlavacek is a computational biologist and managing member who applies AI-driven, Bayesian and mechanistic modeling to dissect complex cell signaling, immunology, and cancer systems. With over two decades of research at institutions including Los Alamos National Laboratory and leadership roles spanning academia and industry, he translates theoretical biophysics into actionable drug-combination strategies. He currently leads Tsama Research to build and validate system-level models targeting oncogenic drivers while maintaining joint appointments at the New Mexico Consortium and the University of New Mexico. Known for bridging rigorous theory with practical validation, he combines deep expertise in systems biology and bioinformatics with a physicist’s quantitative rigor.
An application for parameterization of biological models available in SBML and BNGL formats. Features include parallelization, metaheuristic optimization algorithms, and an adaptive Markov chain Monte Carlo (MCMC) sampling algorithm.
Contributions:1 release, 54 commits, 42 PRs in 1 year 7 months
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William Hlavacek - Managing Member at The University of New Mexico