Xiaoxu Yang
Assistant Professor at University of Utah
Salt Lake City, Utah, United States
Summary
👤
Senior🎓
Top SchoolXiaoxu Yang is an Assistant Professor and computational biologist with a decade of experience developing methods to detect and interpret genomic mosaicism across human tissues. Her lab combines experimental assays and machine learning—most notably DeepMosaic, a control-independent CNN classifier—to reveal somatic and germline mosaic variants that illuminate development, disease, and inheritance. Her work has traced human cortical development, uncovered sperm-borne mutation risks linked to miscarriages and congenital disorders, and identified pathogenic somatic mutations in cortical malformations, with findings published in Nature, Nature Genetics, Cell, and more. She brings a rare blend of hands-on wet-lab assay development (PASM/MPAS) and bioinformatics innovation, plus a track record of building the first noncancer mosaic knowledge base to aid clinical interpretation. Based in Salt Lake City and trained at Peking University, she translates deep genomic signals into actionable insights for genetics and clinical counseling.
10 years of coding experience
15 years of employment as a software developer
Bachelor of Science - BS, Biology/Biological Sciences, General, Bachelor of Science - BS, Biology/Biological Sciences, General at Beijing Normal UniversityDoctor of Philosophy (PhD), Bioinformatics, Doctor of Philosophy (PhD), Bioinformatics at Peking University
Chinese, English
Github Skills (18)
genetics10
classification10
intermediate10
bioinformatics10
genomics10
deep-learning9
sequencing8
prediction-model8
snakemake7
mosaic7
anaconda6
python5
pipeline-framework4
database4
pipeline3
Programming languages (2)
Github contributions (5)
shishenyxx/MosaicBase
Mar 2022 - Dec 2022
MosaicBase is a comprehensive knowledgebase for postzygotic mosaic variants from noncancer disease-related and healthy human individuals
Contributions:14 commits, 4 PRs, 14 pushes in 9 months
knowledgebasehealthybioinformaticsmosaicdisease
XiaoxuYangLab/Sperm_control_cohort_mosaicism
Aug 2020 - Sep 2022
This repository collects pipelines, codes, and some intermediate results for the study of mosaic SNV/Indels for sperm, blood, and other samples of a control cohort.
Contributions:1 release, 103 commits, 10 PRs in 2 years 1 month
indelspipeline-frameworkbloodmosaicanaconda
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